By Joseph R. Bloomer, Hiba Risheg (auth.), Willis C. Maddrey MD, MACP (eds.)
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Extra resources for Atlas of the Liver
In the antigenome, the self-cleavage site is indicated by the open circle. The open reading frame coding for the HDV (delta) antigen has been identified on the antigenome. The smaller form of the HDV antigen is encoded by the region between nucleotides 1598 to 1010, whereas the large form extends to nucleotide 953. (Mapted from Polish et al. ) 195 aa 214 aa Epidemiology and natural history ...... [:::J Very low 0 Low Moderate • High FIGURE ) 2-27. Worldwide prevalence of hepatitis D virus (HDV).
Virion WJ:M Atlas of the Liver I Virion 2-17. Precore (Pre-c) and core (C) messenger RNA (mRNA) transcripts, open reading frames, and products. This schematic diagram illustrates the production of hepatitis B core antigen (HBcAg) and hepatitis B e antigen (HBeAg). The HBcAg is used in the production of hepatitis B virus (HBV) nucleocapsid particles. Part of the signal sequence on the precore protein is cleft off to form HBeAg intermediates, which are further processed by proteolytic cleavage to form the secreted, nonparticulate HBeAg proteins.
Case reports have described the emergence of autoimmune hepatitis after acute hepatitis A and B virus infection [12,15[; minocycline-induced autoimmune hepatitis has ALBERT J. CZAJA been well defined [ 13, 14]; the disease has been reported in patients with HIV [ 16] and after infection with Epstein-Barr virus [ 1 7]; and the measles virus genome has been found more frequently in peripheral blood cells of patients with autoimmune hepatitis than in control patients . Serologic surveys in patients from regions highly endemic for hepatitis C virus (HCV) infection have suggested an etiologic relationship with this virus [9-11 ], and autoimmune hepatitis has been observed after interferon therapy in patients with chronic hepatitis B [ 19].
Atlas of the Liver by Joseph R. Bloomer, Hiba Risheg (auth.), Willis C. Maddrey MD, MACP (eds.)