By National Research Council, Division on Engineering and Physical Sciences, Board on Environmental Studies and Toxicology, Committee on Toxicology, Subcommittee on Acute Exposure Guideline Levels
Super dangerous ingredients (EHSs)² may be published by accident due to chemical spills, commercial explosions, fires, or injuries related to railroad automobiles and vans transporting EHSs. staff and citizens in groups surrounding commercial amenities the place EHSs are synthetic, used, or kept and in groups alongside the nation's railways and highways are very likely liable to being uncovered to airborne EHSs in the course of unintended releases or intentional releases by way of terrorists. Pursuant to the Superfund Amendments and Reauthorization Act of 1986, the U.S. Environmental safety enterprise (EPA) has pointed out nearly four hundred EHSs at the foundation of acute lethality information in rodents. As a part of its efforts to strengthen acute publicity guide degrees for EHSs, EPA and the enterprise for poisonous components and ailment Registry (ATSDR) in 1991 asked that the nationwide examine Council (NRC) enhance instructions for developing such degrees. based on that request, the NRC released guidance for constructing group Emergency publicity degrees for harmful components in 1993. accordingly, ordinary working techniques for constructing Acute publicity guide degrees for harmful elements used to be released in 2001, supplying up to date techniques, methodologies, and different directions utilized by the nationwide Advisory Committee (NAC) on Acute publicity instruction degrees for damaging elements and the Committee on Acute publicity instruction degrees (AEGLs) in constructing the AEGL values. In 1998, EPA and DOD asked that the NRC independently overview the AEGLs built by means of NAC. in line with that request, the NRC equipped inside its Committee on Toxicology (COT) the Committee on Acute publicity instruction degrees, which ready this record. Acute publicity instruction degrees for chosen Airborne chemical substances is the 10th quantity of the sequence and files for N,N-dimethylformamide, jet propellant fuels five and eight, methyl ethyl ketone, perchloromethyl mercaptan, phosphorus oxychloride, phosphorus trichloride, and sulfuryl chloride.
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Additional info for Acute Exposure Guideline Levels for Selected Airborne Chemicals
8% vs. 43% for controls), but the increase did not attain statistical significance. An increased litter incidence of aplasia of some sternebrae was observed in exposed fetuses from both Groups I and II (Group 1: 12/18 vs. 3/19 for controls; Group II: 11/17 vs. 5/20 for controls). No treatment-related adverse effects were observed in dams or pups that were allowed to deliver their offspring. Groups of 22 or 23 impregnated Long Evans rats inhaled DMF at measured concentrations of DMF at 0, 18, or 172 ppm dissolved in polyethylene glycol 400 (20 mm3/L air) for 6 h/day during GD 6-15 (Kimmerle and Machemer 1975).
1983; NTP 1992). I. Dupont de Nemours & Co. 1992); a more recent study found that chronically inhaled DMF produced hepatocellular adenomas and carcinomas in rats at 400 ppm or 800 ppm, respectively, and hepatoblastomas and hepatocellular adenomas and carcinomas in mice at 200 ppm and above (Senoh et al. 2004). An AEGL-1 value was not recommended because data pertaining to end points relevant to the AEGL-1 definition were not available. The AEGL-2 derivation was based on the study in which groups of 15 pregnant Himalayan rabbits were exposed to DMF at 0, 50, 150, or 450 ppm for 6 h/day on gestation days (GD) 7-19 (Hellwig et al.
The two surviving rats improved during the 10-day recovery period, and histopathologic examination of the liver revealed resolution of acute hepatic injury in one of the rats. No adverse effects were noted in the concurrent control group. 2. 0 mg/L) and were then observed for at least 15 days (Stasenkova 1961). Mortality data are summarized in Table 1-4. The LC50 (concentration of a substance that is lethal to 50% of the exposed population) as determined by probit analysis was 3,981 ± 187 ppm (calculated by reviewer).
Acute Exposure Guideline Levels for Selected Airborne Chemicals by National Research Council, Division on Engineering and Physical Sciences, Board on Environmental Studies and Toxicology, Committee on Toxicology, Subcommittee on Acute Exposure Guideline Levels